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Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (identify Beforehand applied: bishydroxycoumarin) and causes a lower in anticoagulant activity as measured by the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to greater metabolism and lowered anticoagulant response of oral anticoagulants (e. As Sy